already existing compounds.
Framework
Drug repurposing involves researching of existing drugs or previously studied but unapproved compounds for new therapeutic uses other than the originally intended indications.
Our approach in repurposing uses Mendelian Randomization which demonstrates statistical significance of the simulated drug efficacy, allowing augmentation of reliability compared to those of the conventional iterative analysis methods.
- Drug targets with known causality of disease occurrence → Expand indication
- Drug targets with unknown causality of disease occurrence → Suggest novel causality & Expand indication
1) Adding new indications to approved drugs
2) Confirming causality and adding new indications to unapproved compounds
Cases of Drug Repurposing
Investigation of antidepressants and antiarrhythmic drugs for uses in obesity
Exploration of new target disease (MR analysis)
Disease Network Construction (Manual)
Calculation of Distance
Decision to repurposing
Credit
- Project Manager
- Jungeun Kim
- Project Assistant
- Eungyo Kim, Jihye Lee, Eunbyeol Lee
- Project Leader
- Yeonbin Jeong
- AI/Algorithm Developer
- Yeonbin Jeong